泛癸利酮对小鼠免疫系统功能影响的研究

Influence of Ubidecarenone on the Immune Function of Mice

目的观察泛癸利酮对正常小鼠免疫系统功能的影响。方法将泛癸利酮按4．2～25．0mg·kg^-1灌胃小鼠30d后，分别测定脾淋巴细胞增殖转化功能，迟发性变态反应性，血清溶血素，抗体生成细胞，腹腔巨噬细胞吞噬鸡红细胞能力，碳廓清能力和自然杀伤细胞（NK）杀伤活性。结果泛癸利酮可明显提高小鼠脾淋巴细胞转化能力、增强变态反应性、增加溶血空斑数、增强腹腔巨噬细胞吞噬鸡红细胞能力、增强NK细胞杀伤活性，均差异有显著性（P〈0．05）。而血清溶血素、碳廓清能力增加则不明显，各组间差异无显著性（P〉0．05）。结论泛癸利酮具有增强机体免疫功能的作用。

Objective To investigate effects of ubidecarenone on the murine immune system. Methods Mice were i.g. given with 4, 2 - 25 mg·kg^-1 for 30 days. The splenocyte proliferation, delayed type hypersensitivity, serum antihemolysin, antibody-forming cells, chicken red cells phagocytosis by macrophages, carbon clearance and natural killer （NK） cell function were investigated after administration. Results Compared with the control group, both spleen lymphocytes proliferation and delayed type hypersensitivity reaction were improved significantly; the number of hemocytolysis plaque was increased, the macrophage＇s activity and NK cell function were enhanced as well （P〈0.05 ）. No apparent differences of carbon clearance and antihemolysin were observed among groups （ P〉0.05 ）. Conclusion Ubidecarenone posses the strengthening effects on immune system.