(Z)-3-丁烯基-4,5-二羟基苯酞的合成

SYNTHESIS OF (Z) 3 BUTYLIDENE 4,5 DIHYDROXYPHTHALIDE

（Ｚ）－３－丁烯基苯酞和它的衍生物广泛地存在于微形科植物，如当归、川芎等，这些植物有些是重要的中药材。（Ｚ）－３－丁烯基－４，５－二羟基苯酞是（Ｚ）－３－丁烯基苯酞的类似物；它对前列腺素Ｆ２α具有抑制作用。本文以３，４－二甲氧基苯甲醇（２）或价廉易得的胡椒醇（６）为起始原料，分别经四步反应顺利地合成了（Ｚ）－３－丁烯基－４，５－羟基苯酞（１）。第一步是本方法的关键，即利用杂原子诱导的区域选择性的芳环直接锂化反应，仅一步反应就建立了碳骨架。

[Z) 3 Butylidenephthalide and its derivatives were isolated as the Umbelliferae which are used frequently as an ingredint in the prescriptions of traditional Chinese medicione.(Z) 3 Butylidene 4,5 dihydroxyphthalide(1),a inhibitor of prostaglandin F2α,is a similar to (Z) 3 bytylidene Phthalide.Their syntheses have been achived in 4 steps starting from 3,4 dimethoxybenzyl alcohol (2) or 3,4 methyldenedioxybenzyl alcohol (6) employing heteroatom directed lithiation reaction on aromatic compound.