摘要
一步法合成5-(对-羟苯基)-乙内酰脲王军胡永红欧阳平凯(南京化工大学生物工程与科学系南京210009)关键词一步法5-(对-羟苯基)-乙内酰脲水合乙醛酸中图分类号O623.627自从Baeyer发现并分离出乙内酰脲,Strecher确定其结构式为,...
The method of systhesis 5 (p hydroxyphenyl) hydantoin by (HO) 2CHCOOH,H 2NCONH 2 and C 6H 5OH in only one step is proposed,IR spectra of the product is coresponded with the document reported .This paper also studies on the six factors that influence the synthesis of 5 (p hydroxyphenyl) hydantoin and defines the optimal operation conditions∶the feeding ratio of urea to glyoxalic acid is 4∶1,for the first stage,the reaction temperature and the reaction time are 80℃,1h respectively,the feeding ratio of phenol to glyoxalic acid is 3∶1,the reaction temperature and time of the second stage are 90℃,5h respectively.
出处
《化学研究与应用》
CAS
CSCD
1997年第3期307-310,共4页
Chemical Research and Application