奎的平与氯氮平对脑电图影响的对照观察

A contrast observation of quetiapine and clozapine in affecting electroencephalogram

目的探讨奎的平与氯氮平对脑电图的影响及差异性。方法符号CCMD-2-R诊断的精神分裂症患者130例,服用奎的平、氯氮平治疗各65例,分别于服药后2周、4周、6周进行脑电图检测,采用阳性与阴性症状量表(PANSS)观察疗效。结果奎的平组脑电图异常率29.2%,氯氮平组脑电图异常率80%,两组比较差异具有显著性意义(P<0.01),两组药物脑电图异常改变率与临床疗效无关。结论奎的平可引起脑电图异常改变,但其异常程度显著低于氯氮平。

Objective To explore that quetiapine and clozapine made the differences to electroencephalogram respectively. Methods 130 patients who met the CCMD-2-R criteria for schizophrenia were divided into two equal groups treated with quetiapine and clozapine respectively,monitored with electroencephalogram, observed the curative effects with PANSS after the second and the forth and the sixth week respectively. Results The abnormal electroencephalogram incidence was 29% in quetiapine group, and 80% in clozapine group （P 〈 0. 01 ）. The abnormal electroencephalogram changes caused by quetiapine and clozapine did not relate to the clinical curative effects. Conclusion Quetiapine was able to cause the abnormal electroencephalogram changes,but they were inferior to that of clozapine.