五氯酚暴露与肿瘤风险关系的Meta分析

Meta-analysis of association between pentachlorophenol exposure and cancer risk

目的综合分析五氯酚暴露与肿瘤发生与死亡的流行病学资料，研究五氯酚暴露与肿瘤危险性之间的关系。方法通过在线检索文献资料。以Poisson回归分析方法探索五氯酚暴露人群的主要肿瘤死亡率，采用固定效应模型合并分析肿瘤SMR，并分析五氯酚暴露与肿瘤危险性之间的剂量一反应关系。结果美国、加拿大研究的暴露人群各主要肿瘤死亡率接近或低于所在国男性肿瘤死亡率：职业暴露人群的结直肠癌发病率为饮水摄食暴露人群的16．4倍；两国暴露人群肾癌合并SMR=1．34（95％ CI=1.02～1．77）；随着五氯酚暴露程度增加，各主要肿瘤死亡合并相对危险度（RR）随之升高。结论五氯酚暴露与肿瘤死亡风险间存有潜在的剂量一反应关系，职业暴露方式的结直肠癌风险高于饮水摄食暴露，五氯酚暴露可能为职业暴露人群肾癌死亡的危险因素。

Objective The epidemiological data based on the exposure of pentachlorophenol （PCP） and cancer incidence and mortality were analyzed to study the relationship between PCP exposure and caner risk. Methods According to the online search of relevant literatures, Poisson regression was used to analyze mortality rates for major caner sites and fixed-effect model was employed to assess caner SMR. The dose-response relationship between PCP exposure and cancer risk was also analyzed. Results Major cancer mortality rates of exposure populations researched in American and Canadian studies were approximate to or lower than national male cancer mortality rates respectively. The incidence rate of colorectal cancer in occupational exposure population was over 16.4 times in comparison with the population exposed from to drinking water and food. The pooled SMR value of kidney cancer was 1.34（95% CI 1.02 - 1.77）. The pooled RR for major caner mortality increased with the rise of PCP exposure level. Conclusion A potential dose-response relationship between PCP exposure and cancer risk could exist. In comparison with to the population to exposed from the drinking water and food, the risk of colorectal cancer in occupational exposure population was higher. PCP may be one of the risk factors of the kidney cancer in occupational exposure population.