高脂饲料喂养大鼠诱导的脂代谢紊乱对糖代谢及炎症因子的影响

Effects of lipid dysmetabolism in rats induced by high fat diet on glycometabolism and inflammatory factor

目的通过观察大鼠脂代谢紊乱过程中糖代谢及相关炎症因子的变化。方法20只雄性SD大鼠随机分为对照组、脂代谢紊乱组,以相应饲料连续喂养17周,检测实验前后大鼠TC、TG、HDL-C、TNF-α和IL-6,并分别于实验第0、5、11和17周取血检测空腹血糖(FPG)、空腹胰岛素(FINS)和超敏C反应蛋白(hs-CRP)。结果与对照组相比,脂代谢紊乱组大鼠的血清TC、TG、FINS、hs-CRP和IL-6水平显著升高(P<0.05),胰岛素敏感指数(ISI)显著降低(P<0.05)。结论高脂饲料可致大鼠脂代谢紊乱,脂代谢紊乱促使FINS升高及ISI下降。

Objective To investigate the changes of glycometabolism and inflammatory factors of the lipid dysmetabolism in rats induced by high fat diet. Methods 20 male SD rats were divided into the control group and the lipid dysmetabolism group. The rats were administrated the high fat diet for 17 weeks, then body weight, and the contents of TC,TG,HDL-C,TNF-α and IL-6 were measured, and the contents of serum FPG,FINS and hs-CRP were detected at the 5th,11th and 17th weeks respectively. Results In comparison with the control groups, the serum contents of TC, TG, FINS, hs-CRP and IL-6 were increased significantly in the lipid dysmetabolism groups, and the ISI levels were decreased in the lipid dysmetabolism groups （P 〈 0.05 ）. Conclusion The rats were induced by high fat diet to develope the lipid dysmetabolism, the lipid dysmetabolism could induce of the FINS increases and decreases of the ISI.