新生儿深部真菌感染的研究进展

The Study Advancement of Invasive Fungal Infection in Infants

随着极低体质量儿救治水平的提高,新生儿深部真菌感染已成为新生儿重症监护室中日益突出的问题。本文回顾性分析新生儿深部真菌感染的易感因素、高危因素,认为低胎龄儿、极低体质量、使用中心静脉导管、胃肠外营养、气管插管、以及长期应用抗生素特别是三代头孢菌素而致的肠道菌群失调等与新生儿深部真菌感染与有关。近年来,血清1-3-β-D葡聚糖含量用于早期诊断具有较好的灵敏度和特异性。治疗上尚没有一致的意见,不少学者提出预防性治疗的可行性。

With the elevating of remedy level on survivable rate of very low birth weight infant,the invasive fungal infection in infants is becoming a increasingly obviously problem in Neonatal Intensive Care Unit （NICU）. This article retrospectively studied the susceptible factor and risk factor of fungal sepsis in infants, and suggested that low gestational ages, very low birth weight infant,presence of central venous catheter, and use of intravenous lipids,exposed to trachea intubation and use of antibiotics for long term- especially thirdgeneration eephalosporin were associated with fungal sepsis Recently 1-3-β-D-Glucan assay for early diagnosis of invasive fungal infections tests have a better specificity and sensitivity. There is not any unification prescribe of infections, many scholars suggested that prophylactic treatment should be beneficial in prevention of invasive fungal infection in infants.