期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

脂联素与2型糖尿病及其并发症 被引量：8

Adiponectin and type 2 Diabetes Mellitus as well as its Complications
下载PDF
导出
摘要 脂联素是由白色脂肪组织分泌一种细胞因子,其在2型糖尿病的发生、发展中起着重要作用,有利于糖脂代谢,减轻胰岛素抵抗,保护胰岛β细胞功能,并能在一定程度上延缓糖尿病并发症的出现。而脂联素及其受体结构、功能的变化,以及多种因素造成的基因缺陷或表达异常,则导致胰岛素抵抗的发生或加重。针对胰岛素抵抗的治疗药物有些是通过影响脂联素的表达来发挥作用。 Adiponectin is a cytokine secreted by white adipose tissue. It played important roles in the genesis and development of type 2 Diabetes Mellitus. It can regulate the metabolism of lipid and carbohydrate, ameliorate insulin resistance and protect the function of pancreatic islet beta cells, thereby postpone the development of Diabetic complications in some degree. The structural or functional changes of adiponectin and its receptor, gene defection or abnormal expression caused by many factors will result in or aggravate insulin resistance. Many therapeutic drugs alleviating insulin resistance can achieve its efficacy by affecting the expression of adiponectin.
作者 王敬 宋光耀
机构地区 河北省人民医院河北省老年医学重点实验室
出处 《医学综述》 2008年第7期1079-1081,共3页 Medical Recapitulate
关键词 脂联素 2型糖尿病 胰岛素抵抗 胰岛Β细胞 并发症 Adiponectin Type 2 diabetes mellitus Insulin resistance Pancreatic islet beta cell Complication
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献22

  • 1Snijder MB, Heine R J, Seidell JC, et al. Associations of Adiponectin Levels with Incident Impaired Glucose Metabolism and Type 2 Diabetes in Older Men and Women:the Hoorn Study[ J]. Diabetes Care ,2006,29( 11 ) :2498-2503.
  • 2Lara-Castro C, Luo NL, Wallace P, et al. Adiponectin multimeric complexes and the metabolic syndrome trait cluster[ J]. Diabetes, 2006,55 ( 1 ) :249-259.
  • 3Stefan N, Stumvoll M, Vozarova B, et al. Plasma adiponectin and endogenous glucose production in humans[ J]. Diabetes Care ,2003 (26) :3315-3319.
  • 4Fu YC,Luo NL, Richard L, et al. Adiponectin promotes adipocyte differentiation,insulinsensitivity, and lipid accumulation [ J ]. Lipid Res,2005,46 (7) : 1369-1379.
  • 5Karbowska J, Kochan Z. Role of adiponectin in the regulation of carbohydrate and lipid metabolism[J]. J Physiol Pharmacol,2006, 57 Suppl 6 : 103-113.
  • 6Matthias B, John W, Bullen J,et al. Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle:associations with metabolic parameters and insulin resistance and regulation by physical training [ J ]. J Clin Endocrinol Metab, 2006,91 (6) :2310-2316.
  • 7Kubota N, Yamauchi T, Tobe K, et al. Adiponectin-dependent and independent pathways in insulin-sensitizing and antidiabetic actions of thiazolidinediones [ J ]. Diabetes,2006,55 ( S2 ) : S32-S38.
  • 8Nawrocki AR,Rajala MW,Tomas E,et al. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor-γ agonists [ J]. J Biol Chem,2006,281 (5) :2654-2660.
  • 9Vasseur F, Helbecque N,Dina C ,et al. Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocytesecreted adiponectin hormone levels and contributeto the genetic risk for type 2 diabetes in French Caucasians [ J ]. Hum Mol Genet, 2002, 11 (21) : 2607-2614.
  • 10Hara K,Boutin P,Mori Y,et al. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population [ J ]. Diabetes, 2002, 51 ( 2 ) : 536-540.

二级参考文献19

  • 1顾卫琼,陈名道,顾元骏,唐金凤,孙首悦,刘长勤,洪洁,张翼飞,李小英,宁光.脂联素受体在胰岛细胞表达,脂联素促进胰岛素的分泌[J].中华内分泌代谢杂志,2005,21(1):68-70. 被引量：34
  • 2Iwaki M, Matsuda M, Maeda N, et al. Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes, 2003,52:1655-1663.
  • 3Yamauchi T, Kamon J, Ito Y, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003,423:762-769.
  • 4Kharroubi I, Rasschaert J, Eizirik DL, et al. Expression of adiponectin receptors in pancreatic β cells. Biochem Biophys Res Commun, 2003,312:1118-1122.
  • 5Schuit FC, Huypens P, Heimerg H et al. Glucose sensing in pancreatic β-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus. Diabetes, 2001,50:1-11.
  • 6Yamauchi T, Kamon J, Minokoshi Y, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med, 2002,8:1288-1295.
  • 7da Silva Xavier GS, Leclerc I, Salt IP, et al. Role of AMP-activated proten kinase in the regulation by glucose of islet beta cell gene expression. Proc Natl Acad Sci USA, 2000,97:4023-4028.
  • 8Berg AH, Combs TP, Du X, et al. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med, 2001,7:947-953.
  • 9Yamauchi T, Kamon J, Waki H, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med, 2001,7:941-946.
  • 10Combs TP, Pajvani UB, Berg AH, et al. A transgenic mouse with a deletion in the collagenous domin of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity.Endocrinology, 2004,145:367-383.

共引文献35

同被引文献123

引证文献8

二级引证文献34

医学综述
2008年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部