摘要
目的:评价低剂量长疗程氟尿嘧啶(5-Fu)静脉泵持续滴注治疗老年晚期胃癌的客观疗效及毒副反应。方法:117例老年晚期胃癌,采用低剂量5-FU 375mg/d静脉泵持续24小时滴注,连用21天,联用低剂量亚叶酸钙(CF)25mg/m^2、羟基喜树碱(HCPT)10mg和/或顺铂(PDD)10mg,每周各连用5天,共用3周。4周为1个周期,化疗2个周期。结果:117例患者均可评价疗效,获得cR9例(7.7%),PR58例(49.6%),RR67例(57.3%)。毒副反应主要为口腔炎(63.2%)、口腔溃疡(38.5%)、恶心呕吐(36.8%)、腹泻(30.8%)、粒细胞下降(25.6%)、便秘(17.9%)和静脉炎(6.0%),主要为I~Ⅱ级毒副反应,对症处理后均能缓解。结论:低剂量长疗程5-Fu持续滴注治疗老年晚期胃癌患者疗效好,毒副反应不严重,一般均能耐受,值得进一步研究。
Objective:To evaluate the objective anti-tumor efficacy and safety of low dose of fluorouracil(5-FU) continuous infusion for a long time by syringe driver for the elderly with advanced gastric cancer. Methods: One hundred and seveteen cases of elderly advanced gastric cancer were treated with low dose of 5-FU 375mg/day continuous infusion for 24 hours by syringe driver for 21 days with low dose of leucovorin 25mg/m^2 and(or) hydroxy camptothecine 10mg/day and(or) cisplatin lOmg/day for 5 days every week during the 3 weeks. This regimen was repeated every 4 weeks. All the patients received 2 cycles. Results : All cases could be evaluated. The overall response rate was 57. 3%, including 9 cases complete response (7.7%) and 58 cases partial response (49.6%). The major toxicity included mucositis, nausea/vomiting, diarrhea and neutropenia phlebitis. Most side effects were grade I~II which were tolerable for the elderly patients. Conclusion: The regimen is an effective chemotherapy for the elderly with advanced gastric cancer. The adverse reactions were not severe. Further clinical study should be warranted.
出处
《临床肿瘤学杂志》
CAS
2008年第3期239-242,共4页
Chinese Clinical Oncology
关键词
胃肿瘤
氟尿嘧啶
持续点滴
化学疗法
老年人
Gastric cancer
Fluorouracil
Continuous infusion
Chemotherapy
The elderly