抑癌基因P53专题文献计量研究

BIBLIOMETRIC ANALYSIS OF PUBLICATIONS ON P53 GENE

Ｐ５３基因是与人类肿瘤关系最为密切的肿瘤抑制基因，有大量相关论文发表。为了探索这一专题的研究现状及趋势，作者根据文献计量方法，利用中国医科大学编制的统计分析软件，对世界权威医学数据库ＭＥＤＬＩＮＥ收录的该专题１９９１—１９９６年的全部相关论文进行主题词及副主题分析。结果表明，研究主要集中在Ｐ５３生物活性及作用机理，Ｐ５３突变的流行病学研究及突变谱分析等方面。不同肿瘤各有研究侧重，且每年都有新热点。预计在一段时间内，有关Ｐ５３如何发挥生理功能，抑制肿瘤生成，调节细胞生长及如何参与肿瘤发生过程等研究，将是无可争议的研究热点。

P53 is a tumor suppressor gene involved in many human cancers,on which a lot of papers have been published.Exploring the status and trend of the research would benefit project researchers.We searched out all the papers published during 1991-1995 from MEDLINE,the most authoritative medical database,and analyzed the subject headings and subheadings of the papers with the biostatistic program by China Medical University Library.We found that the current studies focused on the biological activities of p53 gene,the mechanisms of its tumor suppressing,the molecular epidemiology of p53 mutation,and its mutation spectra.We also found that the study progressed rapidly with new hot topics emerged every year.We conclude that future studies will concentrate on how p53 functions normally,how it controls cell growth and how it suppresses tumorigenesis.