摘要
采用果蝇致畸试验，果蝇伴性隐性致死试验和果蝇非整倍体试验对避孕药醋炔诺酮肟进行致畸和致突变性研究。结果表明当醋炔诺酮肟在浓度分别为５ｍｇ／ｍｌ和５０ｍｇ／ｍｌ时，不引起果蝇致畸率和伴性隐性致死率升高。但在５０ｍｇ／ｍｌ浓度时可引起果蝇非整倍体频率上升，并具有统计学意义。
Norethisterone acetate 3 oxime is a newual contraceptive drug whose teratogenicity and mutagenicity is unclear.In this Paper,in order to investigate safety of norethisterone acetate 3 oxime,we studied the teratogenicity and mutagenicity of norethisterone acetate 3 oxime using Drosophila melanogaster teratogenicity test,sex linked recessive lethal test and aneuploid test.The results showed that norethisterone acetate 3 oxime didn't induce to increase of teratogenic rate and lethal rate in Drosophila melanogaster at concentration 5mg/ml and 50mg/ml.But aneuploid frequency which norethisterone acetate 3 oxime induced in Drosophila melauogaster at concentration 50mg/ml was 0.105% and had significant diffence(P<0.01) compared with positive control.The reason was unclear.
出处
《癌变．畸变．突变》
CAS
CSCD
1997年第5期288-292,共5页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
避孕药
醋炔诺酮肟
毒性
动物实验
致畸性
突变
Norethisterone acetate 3 oxime
Drosophila melanogaster teratogenicity test
Sexed linked recessive lethal test
Aneuploid test
