兔孤束核腹外侧区微量注射谷氨酸钠及甘氨酸对膈神经放电的影响

EFFECTS OF MICROINJECTION OF SODIUM GLUTAMATE AND GLYCINE INTO VENTROLATERAL NUCLEUS OF TRACTUS SOLITARIUS ON THE DISCHARGES OF PHREMC NERVE IN RABBITS

实验在40只麻醉、制动、断双侧颈迷走神经和人工通气的家兔上进行。在孤束核腹外侧区微量注射神经元胞体兴奋剂谷氨酸钠和抑制剂甘氨酸，探讨膈神经放电的变化。结果：微量注射谷氨酸钠，可使膈神经放电脉冲数明显增加，吸气时程延长，呼气时程缩短，呼吸频率变化不明显；微量注射甘氨酸，则膈神经放电脉冲数显著减少，甚至停止，吸气时程缩短，呼气时程不规则延长，呼吸频率降低。上述结果提示：孤束核腹外测区对呼吸节律的形成具有重要的影响。

The effects of microinjection of sodium glutumate and glycine into ventrolateral nucleus of tractus soliturius (VLNTS)on the discharges of phrenic nerve were observed on 40 anaesthetized, vagotomized, paralyzed and artificially ventilated rabbits. The results were as follows: Phrenic nerve discharges were increased, inspiratory duration prolonged, expiratory duration shortened and respiratory frequency not changed by microinjection of sodium glutamate into VLNTS. While by microinjection of glycine,phrenic nerve discharges were decreased, even abolished, inspiratory duration shortened, expiratory duration irregularly prolonged and respiratory frequency decreased.The above results show that VLNTS exert important effects on the genesis of respiratory rhythm.