摘要
目的:探讨紫杉醇联合顺铂治疗晚期非小细胞肺癌的临床疗效和毒副反应。方法:晚期非小细胞肺癌患者30例,紫杉醇175mg/m2,d1,3h静滴;顺铂25mg/(m2·d),d1-d3,21天-28天为一周期。化疗2周期以上,然后按WHO标准评价临床疗效和毒副反应。结果:30例患者均可评价疗效,CR1例,PR12例,NC14例,PD3例,总有效率43.3%,主要的毒副反应为骨髓抑制、肌肉酸痛、恶心呕吐等,患者均可耐受。结论:紫杉醇联合顺铂治疗非小细胞肺癌是一种疗效高,毒副作用可耐受的化疗方案,值得推广。
Objective：To study the efficacy and toxiocitiies of paclitaxel and cisplatin of the treatment of advanced non - small cell lung cancer （NSCLC）. Methods： A total 30 of cases with non - small cell lung cancer enrolled in this study. Paclitaxel 175mg/m^2 3 housr dl, followed by cisplatin 25mg/（ m^2. d） 2 hours dl -3. The patients were repeatedly treated every 21 days. The efficacy and toxicity were evaluated by standard of WHO after no less than 2 cycles. Results： All 30 cases were available for objective response, CR 1 cases, PR 12 cases, NC 14 cases and PD 3 cases. The overall response rate was 43.3%. The main side effects were bone marrow depression muscular soreness and nausea/vomiting. The adverse effects were tolerable. Conclusion： The regimen of paclitaxel and cisplatin has good efficacy and tolerable toxicity for patients with advanced non - small cell lung cancer.
出处
《现代肿瘤医学》
CAS
2008年第4期568-569,共2页
Journal of Modern Oncology
关键词
非小细胞肺癌
紫杉醇
顺铂
non- small cell lung cancer
paclitaxel
cisplatin
