胃癌中HIF-1α与Cox-2表达的相互关系及临床病理意义

The relationship and significance of HIF-1α and Cox-2 in gastric cancer

目的:研究HIF-1α与Cox-2在胃癌中表达的相互关系,探讨它们在胃癌的发生发展、浸润和转移中的作用。方法:应用免疫组化SP法检测54例胃癌中HIF-1α、Cox-2的表达情况,探讨HIF-1α、Cox-2与胃癌临床病理因素的关系。结果:HIF-1α在胃癌中的表达率(74.07%)明显高于正常胃组织(0%),P<0.01;HIF-1α的表达与胃癌TNM分期、肿瘤浸润深度和淋巴结转移显著相关,P<0.05或P<0.01。胃癌中Cox-2高表达(62.9%),明显高于正常胃组织(6.67%),P<0.01;Cox-2的表达与胃癌TNM分期、组织学分级和淋巴结转移显著相关,P<0.05。胃癌组织中HIF-1α与Cox-2的表达呈正相关(r=0.305,P<0.05)。结论:HIF-1α和Cox-2在胃癌的发生发展中起重要作用,联合检测可作为判断胃癌恶性程度和预后的指标。

Objective：To study the expression of HIF -1 ot and Cox -2 in gastric cancer and their relationship with tumor angiogenesis,clinicopathologic feature and prognosis. Methods： Immunohistochemical technique was used to detect the expression of HIF - 1 α and Cox - 2 in 54 cases of gastric cancer. The relationship between the expression of HIF - 1 α, Cox -2 and tumor angiogenesis, clinicopathologic feature of patients was analyzed. Results： The positive expression rate of HIF - 1α in gastric cancer（74.07% ） was significantly higher than that in normal gastric tissue （0%）, P 〈0.01 ; The expression of HIF - 1α in gastric cancer was significantly associated with TNM stage, inva- sive depth and lymph - node metastasis, P 〈 0. 05 or P 〈 0. 011 The expression of Cox - 2 in gastric cancers was （62.9%） significantly higher than that in normal gastric tissue （6.67%）, P 〈 0.01 ; The expression of Cox -2 in gastric cancer was significantly associated with TNM stage, histological grade and lymph - node metastasis （P 〈 0. 05 ）. There was a positive correlation between expression of HIF - 1 α and Cox - 2 （ r = 0. 305, P 〈 0.05 ）. Conclusion ： HIF - 1 α and Cox -2 play the very important role in the development of gastric cancer, could be markers in diagnosis of gastric cancer and estimation of prognosis.