摘要
目的:探讨新城鸡疫病毒及β-榄香烯联合处理的自体瘤苗对消化道肿瘤患者T细胞不同亚群免疫平衡的影响。方法:对80例消化道肿瘤患者术后进行自体瘤苗治疗,检测患者手术前、免疫治疗结束后外周血中CD4+、CD8+、CD4+/CD8+比值变化,以及Th1类细胞因子(IL-2、IFN-γ)和Th2类细胞因子(IL-4、IL-10)的变化。结果:瘤苗治疗后,患者外周血T细胞亚群CD4+、CD8+、CD4+/CD8+比值均发生了较明显变化,与治疗前比较差异有显著性(P<0.05),与正常对照组比较差异无显著性;治疗后IL-2、IFN-γ水平上升,而IL-4和IL-10水平下降,与治疗前比较差异有显著性,与正常对照组比较差异无显著性。结论:自体肿瘤疫苗免疫疗法有助于恢复免疫系统平衡,增强机体抗肿瘤免疫能力;纠正肿瘤患者Th1/Th2偏离状态。
Objective :To explore the effects of the new Castle disease virus/β -elemene modified tumor vaccine specific immunotherapy on T cell immune balance. Methods : Eighty patients with digestive tract neoplasm were treated with virus/β -elemene modified tumor vaccine after operation, then were detected the change of CD4^ + , CD8 ^+ , CD4^+/CD8^ + and IL-2 ,IFN -γ,IL -4 and IL - 10 before operation and after immunization. Results: The percentage of CD4^ + , CD8^ + or CD4^ +/CD8^ + and all cytokines were significandy changed after treatment( P 〈 0.05 ), and were not significantly different when compared to control group( P 〉 0.05 ). Conclusion: NDV/β -elemene modified tumor vaccine enhances the anti -virus immune,balances the Th1/Th2 ratio.
出处
《现代肿瘤医学》
CAS
2008年第4期606-608,共3页
Journal of Modern Oncology
基金
新疆生产建设兵团科委科研基金资助(编号:NK2016)
关键词
新城鸡疫病毒
Β-榄香烯
消化道肿瘤
免疫平衡
肿瘤疫苗
newcastle disease virus
β-elemene
digestive fract neoplasm
immune balance
tumor vaccine