糖尿病孕妇胰岛素抵抗与胰岛β-细胞分泌功能变化

Relationship between insulin resistance and pancreatic β-cell in pregnant with diabetes

目的探讨妊娠期糖尿病(GDM)患者胰岛素抵抗及胰岛细胞分泌功能变化。方法测定68例GDM孕妇和70名正常孕妇的空腹血糖、胰岛素,采用自我平衡模型分析法计算胰岛素抵抗指数(HOMA-IR)及胰岛素分泌指数(HOMA-IS)。结果GDM孕妇组HOMA-IR(1.4±0.6)显著高于正常孕妇组(0.5±0.2),差异有统计学意义(P<0.01),而GDM孕妇组HOMA-IS(3.9±0.9)显著低于正常孕妇组(4.4±0.8),差异亦有统计学意义(P<0.05)。结论胰岛素抵抗增加及胰岛β-细胞的分泌功能下降可能是GDM的发病原因。

Objective To investigate the insulin resistance and pancreatic β-cell function of the pregnant with gestational diabetes mellitus（GDM）. Methods In 68 cases of GDM pregnant group and 70 cases of normal control group, the levels of blood glucose and insulin were measured, the insulin resistance index （HOMA-IR） and β-cell function index （HOMA-IS） were calculated with HOMA model. Results HOMA-IR in the GDM group（ 1.4±0.6） was higher than that in the normal control group（0.5±0.2 ） （ P 〈 0.01 ）. HOMA-IS in the GDM group （3.9±0.9 ） was lower than that in the normal control group （ 4.4±0.8） （ P 〈 0.05）. Conclusion Increasement of insulin resistance and decline of pancreatic β-cell function may result in gestational diabetes mellitus.