注射用头孢唑肟钠与炎琥宁配伍稳定性考察

Stability of Ceftizoxime Sodium for Injection Mixed with Potassium Dehydroandrographolide Succinate for Injection

目的:考察注射用头孢唑肟钠与炎琥宁配伍的稳定性。方法:在25℃下,观察配伍液在8 h内的外观、pH值变化,并用紫外分光光度法测定其含量变化。结果:两药在氯化钠注射液(9.0 mg/mL)中配伍8 h内各项变化均无显著性。结论:注射用头孢唑肟钠与炎琥宁在氯化钠注射液(9.0 mg/mL)中配伍在室温下8 h内基本稳定。

Objective： To study the compatible stability of ceflizoxime sodium for injection mixed with potassium sodium dehydroandrographolide succinate for injection. Methods： At 25℃ for 8 hours,the changes in appearance and pH value were observed and the content was determined by ultraviolet spectrophotometry. Results： No significant changes were found in 8 hours for two injections mixed in 0.9% sodium chloride injection. Conclusion： At room temperature for 8 hours, the mixture of ceftizoxime sodium for injection and potassium sodium dehydroandroandrographolide succinate for injection was stable basically in 0.9% sodium chloride injection.