地红霉素微囊制备及体外释放度的考察

Preparation of Dirithromycin Microcasule and Study on Its Release in Vitro

目的:制备地红霉素微囊并考察其体外释放度。方法:选用生物降解材料明胶和阿拉伯胶为囊材,采用复凝聚法制备流动性粉末状地红霉素微囊。填充胶囊后与参比制剂比较体外释放行为。结果:与参比制剂比较,微囊释放度明显的提高。结论:地红霉素制成微囊剂型后,减少副作用的同时,体外释放度明显的提高。

Objective： To prepare the microcapsules of dirithromycin and to study its release rate in vitro. Methods： Select biodegradable materials and the Arab plastic materials for gelatin capsule, employing complex coacervation to prepare liquidity dirithromycin microencapsulated powder. After filling capsules, compare the release behavior in vitro with that of the reference preparation. Results： Compared with the reference preparation, microcapsules release in vitro was markedly improved. Conclusion： The preparation of dirithromycin microcapsules has reduced the side effects. At the same time the release has been significantly improved.