比浊法C-反应蛋白水平对慢性阻塞性肺疾病急性加重未见预测价值

Effectiveness of turbidity method C-reaction protein in prognosis for acute exacerbation of chronic obstructive pulmonary disease

目的探讨血清C-反应蛋白（CRP）水平对慢性阻塞性肺疾病（COPD）是否出现急性加重的预测价值。方法65例COPD患者为研究对象，用免疫透射比浊法测定其就诊次日清晨静脉血的CRP水平，患者按CRP水平分为CRP阳性组（CRP≥8mg／L，34例）和CRP阴性组（cRP〈8mg／L，31例），随后追踪观察两组1年内COPD急性加重例数并进行比较。结果经回顾性分析，CRP阳性组有21例，CRP阴性组有14例在1年内出现COPD急性加重。经x。检验，两组1年内出现COPD急性加重率差异无统计学意义（P〉0．05）。结论用免疫透射比浊法测定就诊次日清晨静脉血的血清CRP水平对COPD患者在1年内是否出现急性加重未能见到预测价值。

Objective To assess the effectiveness of serum C-reactive protein（CRP） in the prognosis of the acute exacerbation of chronic obstructive pulmonary disease （COPD）. Methods Sixty-five patients with COPD were taken as study subjects. Their serum CRP concentration was measured on the second day of hospitalization. According to the CRP levels measured,the study subjects were divided into two groups,CRP positive group （CRP≥8 mg/L,34 cases）and CRP negative group （CRP〈8 mg/L,31 cases）. In the subsequent one year, the two groups were observed and compared in terms of the instances of the acute exacerbation of COPD. Results According to the retrospective observation,in the duration of one year,there were 21 cases of acute exacerbation of COPD in CRP positive group and 14 cases in CRP negative group. The difference in acute exacerbation between two groups is insignificant （ P 〉 0.05 ）. Conclusions The initial measurement of serum CRP concentration in the COPD patients by the immunity-turbidity method （on the second clay of hospitalization） has proven to be ineffective in the prognosis for acute exacerbation of COPD in one year.