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胞嘧啶鸟嘌呤二核苷酸的免疫作用及调节Th1／Th2细胞因子的意义

Immune effects of CpG-DNA and action of balancing Th1/Th2 cytokines secretion
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摘要 非甲基化的胞嘧啶鸟嘌呤二核苷酸（CpGDNA）可激活多种免疫效应细胞，诱导并增强天然和获得性免疫应答。CpG DNA具有免疫调节作用，能诱导Th1细胞因子产生，抑制Th2细胞因子的释放，并使Th2向Th1转变，其在疫苗佐剂、支气管哮喘、肿瘤的防治中有着广阔的应用前景。 Synthetic oligodeoxynucleoties containing unmethylated CpG motifs （CpG DNA） can trigger the activation of various immune cell subsets, induce and increase innate or acquired immune responses. CpG DNA can adjust immunity. It can induce Th1 cytokines and reduce Th2 cytokines, and change Th2 cytokines into Th1 cytokines. CpG DNA has a widespread prospect in the immune adjuvants, therapy of asthma and tumor.
作者 黄维琳 刘荣玉
机构地区 安徽中医药高等专科学校
出处 《国际呼吸杂志》 2008年第7期421-425,共5页 International Journal of Respiration
关键词 胞嘧啶鸟嘌呤二核苷酸 免疫调节 T细胞 CpG motifs Immune regulate T immune cell
分类号 R3 [医药卫生—基础医学]
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参考文献29

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国际呼吸杂志
2008年 第7期

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