睡眠呼吸暂停低通气综合征与冠状动脉粥样硬化性心脏病关系探讨被引量：2

Relationship between obstructive sleep apnea hypopnea syndrome and coronary artery disease

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摘要阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者中冠状动脉粥样硬化性心脏病（CAD）的发病率增高，心肌缺血事件发生频繁，CAD合并OSAHS患者预后较差，OSAHS是独立于年龄、性别、体质量指数影响CAD的发病和进展的因素。OSAHS患者全身的炎性和氧化应激反应、血液流变学改变、血液动力学改变参与了CAD的发病和进展，它们之间的确切发病机制、遗传、治疗和预后将成为今后的研究热点。 There is an increased morbidity of coronary artery disease（CAD） ,higher rate of myocardial ischemia in patients with obstructive sleep apnea hypopnea syndromes（OSAHS） and worse prognosis among these patients. It is proved that OSAHS is a factor independent of age, sex, body mass index, which influence the CAD and ischemic heart diseases. The mechanisms refers to systematic inflammation, oxidative stress, altered hemorheology and hemodynamics. The exact pathogenic mechanism, genetics, therapy will become a hot research spot in the future.

作者龚娟妮郭兮恒

机构地区首都医科大学附属北京朝阳医院呼吸疾病研究所

出处《国际呼吸杂志》 2008年第7期444-447,共4页 International Journal of Respiration

关键词阻塞性睡眠呼吸暂停低通气综合征冠状动脉粥样硬化性心脏病全身炎症反应氧化-应激反应血液流变学血流动力学 Obstructive sleep apnea hypopnea syndromes Coronary artery disease Inflammation Oxidative stress Hemorheology Haemodynamics

分类号 R766 [医药卫生—耳鼻咽喉科]

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