胰腺实性假乳头状肿瘤研究进展

Progress of solid- pseudopapillary tumor of pancreas

胰腺实性假乳头状肿瘤（SPT）是一种低度恶性胰腺肿瘤，其发病机制与结肠腺瘤性息肉病基因（APC）和β-catenin通路改变及β-catenin基因突变相关。该肿瘤可能来源于多能干细胞，与孕激素受体关系密切。肿瘤细胞围绕纤维血管复层排列而形成假乳头状突起是特征性组织学改变。虽然大部分肿瘤呈良性过程，但具有侵袭性行为。手术切除是首选治疗，预后良好。

Solid-pseudopapillary tumors of pancreas（SPT） are uncommon low malignant tumors of the pancreas that most frequently affect young females. Its pathogenesis may be associated with the alterations of the APC/β-catenin pathway and β-catenin gene mutations. SPT may be derived from muhipotent stem cells and have significant relation with progesterone receptors. Histological features are psudopapillary structure with a fibrovascular core. There is a benign clinical course in the most SPT, but the tumor has a aggressive behavior. Only a small minority of surgically resected tumors recur or develop metastasis. Complete removal is the most perfect treatment with a good prognosis.