摘要
目的探讨影响晚期非小细胞肺癌（NSCLC）预后的重要因素。方法收集2003年1月至2004年9月139例晚期NSCLC患者临床资料，所有病例经细胞病理学或组织病理学确诊。分析性别、年龄、病理类型、临床分期和治疗方式对预后的影响，用乘积极限法计算生存率，用对数秩和检验（Log—rank）检验生存率差别，再用Cox多因素回归对预后因素进行分析。结果本组晚期NSCLC总的中位生存期8个月，6个月生存率59．9％，12个月生存率35．8％，24个月生存率14．3％。治疗方式分为手术加化疗、化疗加放疗、单纯化疗和对症治疗4组，其24个月生存率分别为46．4％、32．2％、9．5％、3．0％，生存率差异有统计学意义（P〈0．05）。结论治疗方式是影响晚期NSCLC预后的重要因素。
Objective To explore the prognostic factors of advanced non-small cell lung cancer. Methods 139 cases of advanced non-small cell lung cancer were analyzed in sex,age,clinical stage,pathology and therapy. All the cases were cytopathologically or histopathologically proved. Product limit method was used to calculate the survival rate, its significance was tested by Log-rank test, factors related to the prognosis were analyzed by the method of Cox regression analysis. Results The overall median survival time was 8 months ,6- month survival rate was 59. 9%, 12-month survival rate was 35.8% ,24-month survival rate was 14. 3%. The 24-month survival rate was 46.4% in treatment with operafiom plus chemotherapy,32. 2% in chemotherapy plus radiotherapy ,9. 5% in treatment with chemotherapy alone ,3.0% in treatment with best supportive care （ P 〈 0. 05 ）. Conclusion Different treatments are important factors affecting prognosis of advanced non-small cell lung cancer.
出处
《国际肿瘤学杂志》
CAS
2008年第3期236-238,共3页
Journal of International Oncology
关键词
癌
非小细胞肺
存活率
预后
Carcinoma,non-small cell lung
Survival rate
Prognosis
