脂联素与1型糖尿病肾病及可溶性血管细胞黏附分子-1的关系

Relation between serum levels of adiponectin and soluble vascular cell adhesion molecule and diabetic nephropathy in type 1 diabetes mellitus

目的:探讨1型糖尿病患者血清脂联素与肾小球滤过率之间的关系。方法:用酶联免疫法对75例1型糖尿病患者和40例对照组血清脂联素和可溶性血管细胞黏附分子-1水平进行测定。结果:1型糖尿病患者血清脂联素水平明显高于对照组[(17.47±6.36)μg/mL vs(13.98±5.63)μg/mL,P<0.01)],且脂联素与肾小球滤过率呈负相关,与可溶性血管细胞黏附分子-1呈正相关。结论:1型糖尿病患者血清脂联素与患者的肾功能减退密切相关,并与内皮和血管损伤有关。

Objective To analyze the relationship between serum levels of adiponectin and soluble vascular cell adhesion molecule and renal function in type 1 diabetes mellitus. Methods Clinical history of 75 cases of type 1 diabetes mellitus were reviewed. Results （1） Significant differences in serum levels of adiponectin were observed between the patients （17.47 ± 6.36） μg/mL and control subjects （13.98±5. 63）μg/mL, （P〈0.01）. （2） There were inverse correlations between adiponectin and BMI, insulin, WHR, fasting TG and glomerular filtration rate, and positive correlations between adiponectin and sVCAM-1 HDL, LDL, and total cholesterol. Conclusion Increased adiponectin level is observed in type 1 diabetic patients and is positively associated with impairment of renal function, and there is a positive association between adiponectin and endothelial damage.