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视网膜内节细胞轴突定向发育的分子基础 被引量：1

Molecular mechanisms of ganglion cell axon guidance in retina
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摘要 在视觉系统的发育过程中,钙黏素、硫酸软骨素蛋白多糖、Slit、细胞黏附分子L1、Eph/ephrin、Sonic hedgehog等分子在视网膜内节细胞轴突定向发育的过程中发挥了关键的作用。而这些轴突定向影响因素,对视神经损伤和中枢神经疾病的治疗同样有积极的指导意义。 In the developing process of visual system, molecules such as cadherins, chondroitin sulfate proteoglycans, Slit, L1, Eph/ephrin, Sonic hedgehog are key regulators of ganglial cell axon guidance decisions to formation of specific axonal pathways in eyes. And these factors are also useful in the treatment of optic nerve injury and central nervous system diseases.
作者 尹小磊 袁容娣 叶剑
机构地区 第三军医大学大坪医院野战外科研究所眼科
出处 《眼科新进展》 CAS 2008年第4期306-307,311,共3页 Recent Advances in Ophthalmology
基金 国家自然科学基金资助(编号:30572009) 重庆市自然科学基金资助(编号:2005BB5273 2007BB5087)~~
关键词 视网膜神经节细胞 轴突导向 生长锥 retinal ganglion cells axon guidance growth cone
分类号 R774.1 [医药卫生—眼科]
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参考文献21

  • 1Erskine L,Herrera E. The retinal ganglion cell axon' s journey:insights into molecular mechanisms of axon guidance[J]. Dev Biol 2007,308( 1 ) :1-14.
  • 2Oblander SA, Ensslen-Craig SE, Longo FM, Brady-Kalnay SM. E-cadherin promotes retinal ganglion cell neurite out-growth in a protein tyrosine phosphatase-mu-dependent. mariner [ J]. Mol Cell Neurosci 2007 ;34 (3) :481-492.
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  • 5Oster SF, Deiner M, Birgbauer E, Sretavan DW. Ganglion cell axon pathfinding in the retina and optic nerve[ J]. Semin Cell Dev Biol 2004;15 (1) :125-136.
  • 6尹小磊,叶剑,陈春林.中枢神经损伤再生修复去抑制作用的研究[J].国际眼科杂志,2007,7(1):154-156. 被引量：9
  • 7Monnier PP,Sierra A,Schwab JM,Henke-Fahle S,Mueller BK. The Rho/ROCK pathway mediates neurite growth-inhibitory activity associated with the chondroitin sulfate proteoglycans of the CNS gltal scar[ J]. Mol Cell Neurosci 2003 ;22(3 ) :319-330.
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  • 10Demyanenko GP,Maness W. The L1 cell adhesion molecule is essential for topographic mapping of retinal axons [ J]. J Neurosci 2003:23 (2):530-538.

二级参考文献79

共引文献14

同被引文献16

  • 1尹小磊,叶剑,陈春林.中枢神经损伤再生修复去抑制作用的研究[J].国际眼科杂志,2007,7(1):154-156. 被引量：9
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  • 3Zhi Y,La Q,Zhang C W,et al.Different optic nerve injury sites result in different responses of retinal ganglion cells to brain-derived neurotrophic factor but not neurotrophin-4/5[J].Brain Res,2005,1047(2):224-232.
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  • 6Berry M.Post-injury myelin-breakdown products inhibit axonal growth:an hypothesis to explain the failure of axonal regeneration in the mammalian central nervous system[J].Bibl Anat,1982,23(1):1-11.
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  • 9Gonzenbach R R,Schwab M E.Disinhibition of neurite growth to repair the injured adult CNS:focusing on Nogo[J].Cell Mol Life Sci,2008,65(1):161-176.
  • 10Okano H,Ogawa Y,Nakamura M,et al.Transplantation of neural stem cells into the spinal cord after injury[J].Semin Cell Dev Biol,2003,14(3):191-198.

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眼科新进展
2008年 第4期

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