摘要
目的探讨食道胃联合洗胃方法在家兔灌服乐果急性中毒(AOPP)中的价值。方法20只家兔经口一次性灌服乐果后(35 mg/kg),建立AOPP模型;将20只家兔随机分为实验组(食道胃联合洗胃)和对照组(普通胃管洗胃),各10只;观察家兔的中毒症状(精神状态、分泌物、痰鸣、瞳孔变化)及其症状出现的时间;1 h后洗胃。分别于洗胃后24 h测定家兔血清中的乐果含量、心肌酶谱和胆碱脂酶。结果实验组家兔血中有机磷含量明显低于对照组[(2.32±0.52)vs(4.96±2.27)ng/mL,P<0.05];实验组家兔血中谷草转氨酶、肌酸激酶、乳酸脱氢酶和a-羟丁酸脱氢酶均明显低于对照组[(23.70±5.88)vs(70.90±34.98)、(1426.70±419.77)vs(2959.50±936.71)、(107.20±43.03)vs(506.60±268.96)、(122.80±71.50)vs(526.50±307.10)U/L,P均<0.05];实验组与对照组胆碱脂酶无显著差异[(0.40±0.51)vs(0.30±0.58)kU/L,P>0.05]。结论食道胃联合洗胃效果优于普通胃管洗胃。
Objective to study value of the esophagus associated with stomach gastric lavage in AOPP. Methods twenty rabbits were fed with Rogor after observe symptom of those poisoned rabbits（psychosis, sputum, pupil chang） and register the time of symptom appear. After those rabbits were allocated into two groups at randomly, ten rabbits is experimental group,the other ten rabbits is comparing group. Experimental group with esophagus associated with stomach gastric lavage. Comparing group with common gastric lavage. After 24 hours measure the content of rogor in rabbits＂ blood serum, and analyse the blood serum enzyme. Results the content of rogor in the experimental group rabbits＂ blood less than that of the comparing group＇s [（2.32±0.52）vs （4.96±2.27） ng/mL,P〈0.05], and the experimental group＇s GOT.CK. LDH .a-HBDH less than the comprais group＇s[（23.7±5.88）vs（70.90±34.98）.（1 426.70±419.77）vs（2 959.50± 936.71） .（107.20±43.03）vs（506.6±268.96）U/L.（122.80±71.50）vs（526.50±307.10）U/L], which are obviously different （P〈0. 05）. CHE in the experimental groups with the comprais group[（0.40±0.51）vs（0.30±0.58）kU/L]has no obvious difference（P〉0. 05）. Conclusion the new gastric lavage method is better than the common gastric lavage method.
出处
《实用临床医学（江西）》
CAS
2008年第3期4-6,共3页
Practical Clinical Medicine
基金
江西省卫生厅科技计划资助项目(051071)
