氟比洛芬酯用于骨折后疼痛治疗的疗效观察

Therapeutic Effect of Flurbiprofen Axetil Injection for the Treatment of Pain after Bone External Injury

【目的】观察氟比洛芬酯用于骨折后疼痛治疗的疗效。【方法】急性骨折后疼痛患者40例采用完全随机方法分为A、B两组,A组给予氟比洛芬酯注射液50mg静脉注射,B组给予曲马多注射液100mg肌肉注射,采用视觉模拟评分法(VAS)对镇痛效果及副反应观察比较。【结果】各时点VAS评分A组明显低于B组(P<0.01～P<0.05)。血流动力学MAP、HR之间显著无差异性(P>0.05)。A组镇痛起效时间为(8.13±6.16)min,B组镇痛起效时间为(17.1±9.09)min,两组差异有显著性(P<0.01)。两组的恶心呕吐发生率、头晕、嗜睡、呼吸抑制发生率差异无显著性(P>0.05)。【结论】氟比洛芬酯注射液在骨折后疼痛治疗中具有良好的镇痛作用且副作用少。

[Objective] To observe the efficacy of flurbiprofen axetil injection in bone external injury. [Methods] Forty cases with bone external injury were randomly divided into group A and B. The flurbiprofen axetil injection 50mg were given by intravenous injection in group A. The tramadol injection 100mg were given by intramusclar injection in group B. The analgesic effect and side reaction of drugs were observed comparatively between two groups. [Results] The age, body weight,sex and blood loss were no significant difference between two groups. The VAS of group A was lower than that of group B （ P 〈0.01 or P 〈0.01） ,Analgesic effective time of group A and B were 8.13±6.16 min and 17.1±9.09 min respectively, and there was significant difference between two groups. The side effects such as vomit and nausea were same between group A and B（ P 〉0.05）. [Conclusion]Flurbiprofen axetil injection for the treatment of pain after bone external injury has a good analgesic effect and less side effects.