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雷米普利的药理和临床 被引量:1

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摘要 自1980年卡托利普上市以来,后来发现了许多具有较强酶抑制活性的化合物。Hoechst公司研制的雷米普利(Ramipril,Hoe-498)是其中一个强效、长效、竞争性血管紧张素转化酶(ACE)抑制剂,无卡托普利味觉丧失等副作用,5mg剂量1小时抑制ACE几乎100%,72小时为50%,8日后为30%。临床试验表明,对轻或中度高血压患者,每日一次,口服5~20mg即可达到理想的降压效果,且大多数患者需要量少于20mg。本文重点综述其药理作用和临床应用。
作者 岳步星
机构地区 邯郸医药站
出处 《国外医药(合成药.生化药.制剂分册)》 1990年第3期159-162,共4页 World Pharmacy
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