肾癌患者多电极射频消融治疗前后细胞免疫功能的研究

Changes of T lymphocytes and red cell immunity in peripheral blood of patients with primary renal cell cancer after radio-frequency ablation treatment

目的研究肾癌患者接受射频消融治疗前后机体T淋巴细胞及红细胞免疫功能的变化。方法分析29例肾细胞癌患者射频消融治疗前和治疗后7、15和30d外周血淋巴细胞亚群(CD+3、CD+4、CD+8、CD+4/CD+8)和红细胞C3b受体花环(RBC-C3bR)及免疫复合物花环(RBC-ICR)形成率。结果所有肾癌患者在射频消融治疗后7d,CD+3,CD+4,CD+4/CD+8较治疗前明显升高(P<0.05);15d后RBC-C3bR形成率明显高于治疗前,而RBC-ICR形成率低于治疗前(P<0.05)。结论多电极射频消融治疗肾癌,可以改善患者的细胞免疫状态。

[Objective] To study the changes of immune function of patients with primary renal cell cancer （RCC） after radiofrequency ablation treatment. [Methods] 29 cases of RCC patients were treated by using multi-hook radiofrequency ablation （RFA）. The changes in percentages of CD3^＋, CD4^＋, CD8^＋, CD4^＋/CD8^＋ and RBC-C3bR, RBC-ICR were detected before and 7, 15, 30 days after RFA, respectively. [Results] The percentages of CD3^＋, CD4^＋ and the ratio of CD4^＋/CD8^＋ were significantly higher after RFA treatment than before（P 〈0.05）. 15 d After treatment, RBC-C3bR increased obviously, but the RBC-ICR formation rate and CD8^＋ cell were markly decreased（P 〈0.05）. [Conclusion] Multi-hook radiofrequency ablation therapy for the kidney cancer can improve the patient＇s cell immunity status.