抑癌基因p53在原发性肝癌发病中的作用

Role of p53 mutation in carcinogenesis of primary hepatoma

该文通过复习有关p53突变研究的所有文献,并将他们的研究结果做一总结分析,综述了抑癌基因p53突变在肝癌发病中的作用。结果发现:肝癌的发病机制非常复杂,涉及了一系列基因和细胞因子。同时表明肝癌的发病是一个多步骤的过程,在此过程中,HBV和AFB1是两个非常重要的致癌因子,他们可通过激活癌基因或使抑癌基因失活而发挥作用,其中发挥重要作用的基因为p53,p53249编码子的突变在肝癌发病中起着非常重要的作用。p53249编码子的突变可使p53功能丧失,同时也可使与p53相关的信号传导路径发生改变,并与其他因子共同作用,进而导致肝癌的发生。

To review the of role of p53 mutation in carcinogenesis in HCC. Revuewed all the papers on the research of p53 mutation and summarized the results. The carcinogenesis of hepatoma was more complicated, involved a lots of genes and factors. The process of carcinogenesis also involved mutiplesteps. In china, HBV and AFB1 were the two major factors that caused the primary hepatoma, they maybe lead to the hepatoma through the activation of oncogene and disfunction of tumor suppressor gene, such as p53, Rb, TGFbRⅡ etc. The most important genes in the carcinogenesis of hepatoma was p53, and the mutation of p53 in code 249 played a very important role in this process.