糖尿病合并高血压患者血浆尾加压素Ⅱ的变化及临床意义

Change of plasma urotensinⅡ in diabetic patients with hypertension and it clinical significance

目的探讨血浆尾加压素Ⅱ(UⅡ)、内皮素(endothelin,ET)、肾上腺髓质素(ADM)、一氧化氮(NO)变化与糖尿病合并高血压的关系。方法测定20例血压正常、40例合并高血压的糖尿病患者和20例正常对照组血浆UⅡ、ET、ADM、NO水平,分析糖尿病合并高血压与患者血浆UⅡ、ET、ADM、NO水平变化的关系。结果合并高血压糖尿病患者血浆UⅡ、ET、ADM水平较血压正常糖尿病患者明显升高(均P<0.01),血浆NO水平明显降低(P<0.01)。合并高血压糖尿病患者血浆UⅡ、ET、ADM水平与患者平均动脉压(MAP)呈明显正相关(r=0.509,r=0.434,r=0.67,均P<0.01),血浆NO水平与MAP呈明显负相关(r=-0.577,P<0.01)。结论糖尿病患者血浆UⅡ、ET、ADM水平升高、NO水平降低在糖尿病合并高血压的发生发展中起重要作用。

[Objective] To study the relationship between urotensinⅡ, endothelin, adrenomedullin, nitric oxide and hypertention in diabetic patients. [Methods] The concentrations of plasma urotensinⅡ, endothelin, adrenomedullin, nitric oxide were measured in 20 type 2 diabetic patients with normal blood pressure、 40 type 2 diabetic patients with hypertension and 20 normal individuals. To analyse the relationship between plasma levels of urotensinⅡ、 endothelin,adrenomedullin、 nitric oxide and hypertension in diabetic patients. [Results] The results showed that the plasma levels of urotensinⅡ、endothelin and adrenomedullin were significantly higher in the diabetic patients with hypertension than in those with normal blood pressure, while the plasma nitric oxide level was significantly lower （all P 〈0.01）. A positive correlation was found between urotensinⅡ、 endothelin、 adrenomedullin and MAP in diabetic patients with hypertension （r =0.509, r =0.434, r =0.67, all P 〈0.01）, a negtive correlation was found between nitric oxide and MAP also （r =-0.577, P 〈0.01）. [Conclusions] The high plasma concentrations of urotensinⅡ、 endothelin、 adrenomedullin and low plasma concentration of nitric oxide might play an important role in the develpment of hypertension in the diabetic patients.