高尿酸血症与代谢综合征的相关性分析

Analysis of correlationship between hyperuricemia and metabolic syndrome

目的探讨高尿酸血症与代谢综合征之间的关系。方法对319例病人按是否存在代谢综合征及代谢综合征因素多少分组,观察血尿酸与代谢综合征各指标的相关性。结果代谢综合征组体重指数、腰围、收缩压、舒张压、胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、尿酸、糖化血红蛋白、LNHOMA-IS、LNHOMA-IR均高于非代谢综合征组(P<0.01),代谢综合征因素越多,血尿酸水平越高,且腰围、三酰甘油、高密度脂蛋白胆固醇、糖化血红蛋白是影响血尿酸的主要相关因素。结论高尿酸血症与中心性肥胖、高血脂、高血糖关系密切,是代谢综合征的一个重要因素,在代谢综合征的演变与进展中发挥着重要作用。

[Objective] To explore the relationship between hyperuricemia and metabolic syndrome. [Methods] With grouping of 319 patients, according to presence or absence of metabolic syndrome and the number of the factor leading to metabolic syndrome, investigated the relationship of serum uric acid and metabolic parameters. [Results] BMI, waistline, systolic blood pressure, diastolic blood pressure, TC, TG, HDL-C, LDL-C, UA, HbA1C, LNHOMA-IS, LNHOMA-IR in metabolic syndrome group were higher than those in non-metabolic syndrome group （P 〈0.01）, the more factors of metabolic syndrome occurred, the higher mean level of UA was. Logistic regression analysis revealed a significant association between UA and waistline, TG, HDL-C, HbA1C. [Conclusion] Hyperuricemia is related to center obesity, dyslipidemia and hyperglucosmia closely, it＇s one of the important factors of metabolic syndrome. Hyperuricemia has a great effect on metabolic syndrome.