甲氨喋呤在输卵管妊娠保守性手术治疗中的临床分析

Methotrexate effect tubal pregnancy in the conservative on surgical treatment

目的探讨输卵管妊娠保守性手术治疗中局部应用甲氨喋呤的临床效果。方法随机选取261例输卵管妊娠需要行保守手术治疗患者术中用MTX作为观察组。另87例输卵管妊娠需要行保守手术治疗患者术中未用MTX作为对照组。结果输卵管妊娠保守性手术治疗中使用MTX住院时间短,血β-HCG恢复至正常时间短。PEP发生率明显优于对照组(P<0.01)。两组生殖功能结局差异无显著性(P>0.05)。结论输卵管妊娠保守性手术中使用MTX值得应用。

[Objective] To investigate the clinical effects of Methotrexate on the tubal pregnancy with conservative surgical treatment. [Methods] 261 cases randomly selected will need tubal pregnancy in patients with conservative treatment as used MTX group. Another 87 cases of tubal pregnancy needs of conservative surgical treatment in patients with unused MTX as a control group. [Results] Tubal pregnancy conservative surgery for the use of MTX has characteristics as shorter hospitalization, serum β-HCG returned to normal with a shorter time. PEP rate was better than the control group （P 〈0.01）. Reproductive function outcome of the two groups showed no significant difference （P 〉0.05）. [Conclusion] Tubal pregnancy conservative surgery should be used in the application of MTX.