摘要
目的探讨血清胱抑素C(Cys—C)水平在新生儿窒息后肾损伤中的诊断价值。方法窒息新生儿60例按出生时Apgar评分分为轻度窒息组(37例)、重度窒息组(23例);同期选择15例健康足月新生儿作为健康对照组。窒息组新生儿在入院后第1天,健康对照组新生儿在出生1-3d抽取外周静脉血3mL,用免疫比浊法检测各组血清Cys—C水平,并与其血清尿素氮(BUN)、肌酐(Cr)水平比较。采用SPSS12.0软件进行统计学t检验和x^2检验。结果1.在轻度窒息组和重度窒息组中,血清Cys—C水平分别为(1.17±0.18)mg/L和(1.51±0.21)mg/L,血清BUN水平分别为(5.17±2.25)mmol/L和(6.89±2,21)mmol/L,血清Cr的水平分别为(52.59±15.80)μmol/L和(69.19±18.30)μmol/L,健康对照组血清Cys—C、BUN和Cr水平分别为(0.91±0.12)mg/L,(4.35±1.20)mmol/L和(46.55±10.63)μmol/L。与健康对照组相比,轻度窒息组和重度窒息组血清BUN、Cr和Cys—C水平明显升高,差异具有显著性意义(Pa〈0.01);与轻度窒息组相比,重度窒息组血清BUN、Cr和Cys—C水平有显著升高,差异具有显著性意义(Pa〈0.01)。2.轻度窒息组血清Cys—C、BUN和Cr的异常检出率分别为73%、35%和38%;重度窒息组血清Cys—C、BUN和Cr的异常检出率分别为91%、65%和70%。在轻度窒息组和重度窒息组血清Cys—C的异常检出率显著高于血清BUN和Cr的异常检出率,差异具有显著性意义(P〈0.05,0.01)。3.血清Cys—C与BUN和Cr水平之间呈显著正相关关系(r=0.81,0.84P。〈0.01)。结论Cys—C能较早反映肾脏受损时肾小球滤过率的下降。血清Cys—C可作为新生儿窒息后肾损伤的早期诊断指标之一。
Objective To explore the diagnostic value of serum cystatin C ( Cys - C) in kidney injury induced by neonatal asphyxia. Methods The peripheral vein blood 3 mL was drawn out on the asphyxiated newborn infants in the first day and on control group during 3 days, the level of serum Cys -C was detected by immunoturbidimetry in 37 mildly asphyxiated newborns,23 seriously asphyxiated newborns and 15 full term infants, and the level of Cys - C was compared with serum urea (BUN) and creatinlne(Cr). Results 1. The level of Cys - C were ( 1.17 ± 0. 18 ) mg/L and ( 1.51±0. 21 ) rag/L, the level of BUN were ( 5.17 ± 2.25 ) mmol/L and (6.89 ± 2. 21 ) mmoL/L and the level of Cr were(52.59 ± 15.80) μmol/L and(69.19 ± 18.30) μmol/L in mildly asphyxiated newborns and seriously asphyxiated newborns, respectively. The levels of Cys- C,BUN and Cr were (0.91 ± 0.12 ) rag/L, (4.35 ± 1.20) mmol/L and (46.55 ± 10.63 ) μmol/L,respectively. Compared with control group, there were a significant differences,in the level of BUN,Cr and Cys -C, all of which had increased in the cases of mildly asphyxiated newborns and seriously asphyxiated newborns (P 〈 0. 01 ) ;Compared with the mildly asphyxiated newborns, the levels of BUN, Cr and Cys - C had increased in the seriously asphyxiated newborns, the differences were obvious ( P 〈 0.01 ). 2. The abnormal detection rate of Cys - C, BUN and Cr were 73 percent and 35 percent and 38 percent, respectively, in mildly asphyxiated newborns ; the abnormal detection rate of Cys -C, BUN and Cr were 91 percent and 65 percent and 70 percent, respectively, in seriously asphyxiated newborns. The abnormal detection rate of Cys- C was higher than that of BUN and Cr, and the differences were significant (P 〈 0.05,0. 01 ). 3. There were positive correlations (r = 0. 81 ,0. 84 Po 〈 0.01 ) among the levels of serum Cys - C, BUN and Cr. Conclusion Serum Cys - C can be used as a early diadynamic criterion of kidney injury induced by neonatal asphyxia.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2008年第6期452-453,共2页
Journal of Applied Clinical Pediatrics
基金
四川省杰出青年学科带头人培养基金项目资助(04ZQ026-033)
关键词
婴儿
新生
窒息
胱抑素C
肾损伤
infant, newborn
asphyxia
Cystatin C
kidney injury