头孢特仑新戊酯片溶出度测定方法研究

Study on the dissolution of Cefteram Pivoxil Tablets

目的建立紫外-可见分光光度法测定头孢特仑新戊酯片的溶出度方法。方法本试验采用ZRS-6智能溶出试验仪，以0．1mol·L^-1的盐酸溶液900mL为溶出介质，选用紫外-可见分光光度法测定本品的溶出度。结果用此法测定本品的溶出度，头孢特仑在2．7-24．2μg·mL^-1浓度范围内，吸光度与浓度线性关系良好，线性方程为Y=0．0395X＋0．0046，r=0．9999；溶液稳定；平均回收率为99．46％。结论该方法简便、快速、准确，能有效控制该制剂的质量。

OBJECTIVE To establish an ultraviolet spectrophotometry （UV） method for the determination of the dissolution of Cefteram Pivoxil tablets. METHODS Intellectual diffusion meter（ZRS-6）was used to determine the dissolution of Cefteram Pivoxil Tablets. 0. 1mol · L^-1 hydrochloric acid solution was used as dissolution medium and the sample was measured by UV speetrophotometry. RESULTS The calibration curve of Cefteram Pivoxil was linear（ r =0. 9999） in the range of 2.7 24.2μg· mL^-1. The linear equation was Y = 0. 0395 X ＋0. 0046, the solution was stability. The recovery rate was 99. 46% CONCLUSION The method was simple.rapid and accurate for quality control of the preparation.