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异种移植超急性与急性排斥反应及其对策研究进展

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摘要 器官移植作为治疗终末期器官衰竭患者的一种比较有效的方法,在临床上得到了越来越广泛的应用,然而这也使人类器官供体相对缺乏的状况越来越严重,激起人们对异种移植的强烈兴趣。考虑到器官的功能特点、形状和大小,基因调控和控制病毒传播的难易程度等因素。使得猪成为理想异种移植供体之一。然而,异种移植后将出现比同种异体移植更为复杂的排斥反应。
出处 《天津医科大学学报》 2008年第1期127-130,共4页 Journal of Tianjin Medical University
基金 国家青年自然科学基金资助项目(30500489)
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参考文献27

  • 1Platt JL, Holzknecht ZE, Lindman BJ.Porcine endothelial cell antigens recognized by human natural antibodies [J]. Transplant Proc, 1994,26(3):1357
  • 2Watts A,Foley A,Awwad M, et al.Plasma perfusion by apheresis through a Gal immune- oaffinity column successfully depletes anti- Gal antibody:experience with 320 apheresis in baboons [J].Xenotransplantation,2000,7 (3):151
  • 3Brandl U, Erhardt M, Michel S, et al. Soluble Galalpha( 1,3)Gal conjugate combined with hDAF preserves morphology and improves function of cardiac xenografts [J]. Xenotransplantation,2007,14 (4): 323
  • 4Mckenzie IFC,Li YQ,Patton K, et al. Fucosyl transferase (H) transgenic heart transplants to Gal-/- mice [J].Transplantation,2000,70 (8):1205
  • 5Sandrin MS, Loveland BE, McKenzie IF. Genetic engineering for xenotransplantation [J]. J Card Surg,2001,16(6):448
  • 6Yeatman M, Daggett CW, Parker W, et al. Complement-mediated pulmonary xenograft injury: studies in swine-to-primate orthotopic single lung transplantmodels [J]. Transplantation, 1998,65 ( 8 ): 1084
  • 7Zhu M, Wang SS, Xia ZX, et al. Inhibition of xenogeneic response in porcine endothelium using RNA interference [J]. Transplantation, 2005,79(3):289
  • 8Lai L, Kolber-Simonds D, Park KW, et al. Production of alpha-1,3- galactosyltransferase knockout pigs by nuclear transfer cloning [J].Science,2002,295 (5557): 1089
  • 9Phelps C J, Koike C, Vaught TD, et al. Production of alpha 1,3 -galactosyltransferase - de - fieient pigs [J]. Science,2003,299 ( 5605 ) :411
  • 10Chen G, Qian H, Starzl T, et al.Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys [J]. Nat Med,2005,11 (12) :1295

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