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2型糖尿病患者FAT/CD36基因启动子区-3489C/T和密码子区478C/T多态性研究 被引量：1

Correlation between fatty acid translocase gene polymorphism and Chinese type 2 diabetes mellitus
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摘要 目的探讨FAT/CD36脂肪酸转位酶基因启动子区-3489C/T和密码子区478C/T多态性与2型糖尿病(T2DM)的相关性。方法运用聚合酶链反应-限制性片段长度多态性技术对196例T2DM患者和120例正常对照者的-3489C/T与478C/T多态性进行检测,并比较各组间基因型频率和等位基因频率以及相关临床资料。结果(1)所有研究对象均无一例存在FAT/CD36基因启动子区478C→T突变,基因型均表现为478CC之纯合子,478CC和478TT等位基因频率分别为1和0。(2)T2DM组和正常对照组的-3489C/T多态性基因型和等位基因频率比较差异无统计学意义,P值分别为0·682和0·683。结论昆明地区的汉族人中FAT/CD36基因的启动子区-3489C/T和密码子区478位C/T多态性与昆明地区汉族人群2型糖尿病的发生无显著相关关系。 Objective To study the correlation between fatty acid translocase （FAT/CD36） gene promoter region -3489C/T and code region 478C/T polymorphism and type 2 diabetes mellitus. Methods -3489C/T and 478C/T polymorphism were screened in 196 type 2 diabetic patients and 119 normal controls by polymerase chain reaction restriction fragment lenth polymorphism method （PCR-RFLP）. Results （ 1 ） All subjects proved to be homozygote wildtypes （CC） for the 478C→T substitution. （ 2 ） No significant differences were found in alleles and genotype frequencies of FAT/CD36 gene-3489C/T polymorphism between diabetic patients and non-diabetic contronls. Conclusions FAT/CD36 gene-3489C/T or 478C/T polymprphism was not significantly associated with type 2 diabetes mellitus in Han people of Yunnan.
作者 曾蓉 严新民 宋滇平 高建梅
机构地区 昆明医学院第一附属医院糖尿病科 云南省第一人民医院基础医学研究所
出处 《中华临床医师杂志（电子版）》 CAS 2008年第3期16-19,共4页 Chinese Journal of Clinicians(Electronic Edition)
关键词 糖尿病 2型 多态现象 遗传 脂肪酸转位酶 Diabetes mellitus,Type 2 Polymorphism, Genetic Fatty acid translocase
分类号 R587.1 [医药卫生—内分泌]
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共引文献9

同被引文献18

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中华临床医师杂志（电子版）
2008年 第3期

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