摘要
目的探讨喹硫平治疗对分裂症患者生活质量的影响。方法以喹硫平与氯氮平治疗分裂症各60例作对照研究,采用简明精神病评定量表、不良反应量表评定疗效及副反应,WHOQOL-BREF量表衡量患者的生活质量。结果最后一次评定,喹硫平组BPRS总分降至(15.52±4.37)分,与治疗前比较有显著性差异(P<0.01);氯氮平组BPRS总分降至(15.98±4.63)分,与治疗前比较有显著性差异(P<0.01)。两组间疗效无显著性差异(P>0.05)。氯氮平组副作用较喹硫平组多。经12个月治疗,喹硫平组的身心健康、心理健康、社会关系、环境因素的分值分别为(71.13±5.63)分、(95.37±11.73)分、(96.31±12.37)分、(95.37±11.92)分,氯氮平组的身心健康、心理健康、社会关系、环境因素的分值分别为(68.31±9.37)分、(78.12±10.34)分、(79.72±12.22)分、(78.65±11.85)分。两组患者生活质量较治疗前均有显著改善(P<0.01),在心理健康、社会关系和环境因素等三方面,喹硫平优于氯氮平(P<0.01)。结论在提高分裂症患者生活质量方面,喹硫平优于氯氮平,有利于分裂症的远期康复。
Objective To investigate influence of quetiapine on quality of life in schizophrenia. Methods A total of 120 schizophrenic patients were randomly treated with quetiapine or clozapine. The Brief Psychiatric Rating Scale （BPRS） and Treatment Emergent Symptoms Scale （TESS） were used to assess efficacy and side effects. WHOQOL-BREF was used to evaluate quality of life. Results At the end of trial,the scores of BPRS decreased to（15.52±4.37） in quetiapine group, which was significantly lower than the baseline （P〈0.01）. The scores of BPRS decreased to（15.98±4.63） in clozapine group,which was significantly lower than the baseline （P〈0.01）. Two groups showed Similar efficacy. The side effects were more in clozapine group than those in quetiapine group. After the treatment of 12 month , the scores of physical health, psychological health, social relationship, and environment in quetiapine group were （71.13±5.63）,（95.37±11.73）,（96.31±12.37）, （95.37±11.92）, and the scores in clozapine group were （68.31±9.37）, （78.12±10. 34）, （79.72±12.22）, （78.65±11.85） respectively. Quality of life in the two groups significantly improved （p〈0. 01）. In the demains of psychological health, social relationship and environment, quetiapine was significant superior to clozapine （p〈0. 01）. Conclusion Quetiapine should improve quality of life in schizophrenic and would be helpful for long-term rehabilitation of patients.
出处
《精神医学杂志》
2008年第2期121-123,共3页
Journal of Psychiatry
