小剂量亚胺培南/西司他丁在肺部感染患者中的药动学及疗效观察

A study on pharmacokinetics and therapeutic efficacy of small dosage of imipenem/cilastatin in patients with pulmonary infection

用小剂量亚胺培南／西司他丁治疗１８例肺部感染患者，通过细菌培养、检测血药浓度动态变化及支气管肺泡灌洗液（ＢＡＬ）的药物浓度测定，以探讨小剂量亚胺培南／西司他丁治疗肺部感染的适用价值。结果显示：致病菌阴转率为８９％，治疗的有效率为８９％；静滴后１．５ｈＢＡＬ中药物浓度为１．３１２±０．１６１μｇ／ｍｌ；血药峰浓度为３７．３２±９．５７μｇ／ｍｌ，用药８ｈ后降为０．９１±０．１１μｇ／ｍｌ，半衰期约为１ｈ。

To estimate the clinical significance of small dosage imipenen in treating pulmonary infcction, 18 cases of pulmonary infection were treated with small dosage of imipenem, bacterial culture was conducted and imipenem concentration in plasma was consecutively measured and that in BAL fluid was also determined. Results showed that the eradication rate of bacteria was 89% and the effective healing rate of imipenem was 89% respectively; imipenem concentration in BAL fluid was 1.312±0.161μg/ml; the peak value of imipenem with a half life of 1h in plasma was 37.32±9.57μg/ml and it was decreased to 0.91±0.11μg/ml 8h later. It was concluded that imipenem can exert good therapeutic efficacy on pulmonary infection for it has optimal permeability in lungs.