高压氧与硝酸甘油治疗急性心肌梗塞的实验研究

An experimental study of hyperbaric oxygenation and nitroglycerin on acute myocardial infarction Yang

目的:探讨高压氧(HBO)和硝酸甘油联合治疗急性心肌梗塞(AMI)的效果。方法:在兔AMI 模型上观察联合应用 HBO 和硝酸甘油、单用 HBO 及单用硝酸甘油的疗效并进行比较;以胸前多导联 ECG、心肌病理染色和血液动力学数据为观察指标。结果:HBO 与硝酸甘油联合治疗方案减轻心肌损伤、缩小梗塞面积、保护心功能的效果显著优于单纯 HBO 或硝酸甘油治疗。结论:硝酸甘油对 HBO 具有协同效应,可明显增强 HBO 对 AMI 的疗效。

Objective:To explore the combinative effects of hyperbaric oxygenation (HBO) and nitro- glycerin on acute myocardial infarction(AMI).Methods:95 rabbits were artificially formed the AMI mod- el.Among them,24 rabbits were treated with HBO and nitroglycerin,24 only with HBO therapy and an- other 24 with nitroglycerin alone.The rest were given the normal saline.The ECG,hemodynamic and my- ocardial histology test were as an evaluted indexes and determined.Finally,the effects were compared in these rabbits.Results:The effects of rabbits with HBO and nitroglycerin were better than those of rabbits with HBO alone or nitroglycerin alone.It is found that the myocardial injury decreased,occluded size re- duced and left ventricular function improved greatly.Conclusions:It is suggested that the HBO combined with nitroglycerin treatment has a synergistic effect for AMI.