摘要
苯骈吡喃类钾通道启开剂作为抗高血压药物正日益引人注目。根据现有构效关系，运用经典的药物设计方法，设计合成了２８个苯骈吡喃肟类化合物。初步药理研究表明，某些化合物有一定程度的扩血管活性。
Considerable attention is being given to the potassium channel openers of benzopyrans as potential therapeutical agents for hypertention Based on the structure activity relationships reported in the literatures and applying the classic theory of drug design, 28 benzopyran 4 one oximes were designed and synthesized Some of them exhibited the vasodilation activity
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1997年第4期193-197,共5页
Journal of China Pharmaceutical University
基金
国家自然科学基金
