发作期^(18)F-FDG PET显像对癫痫灶的定位价值

The value of 18 F FDG PET imaging in the localization of ictal epileptic foci

为评价发作期１８Ｆ脱氧葡萄糖（ＦＤＧ）ＰＥＴ显像在癫痫灶定位中的价值，对１５２例癫痫患者进行了发作期１８ＦＦＤＧＰＥＴ检查，并与发作间期图像比较。结果１５２例发作间期示低代谢区患者发作期均呈高代谢，其中６５例（４２８％）为明显高代谢，８７例（５７２％）为相对高代谢。８０例高代谢灶局限于单叶，７２例多发高代谢灶患者中４９例位于相邻近区域。发作期结合发作间期检查，可排除非致痫灶性低代谢病变和癫痫发作过程中痫性活动的播散，提高癫痫灶定位的特异性。

PURPOSE To assess the value of 18 F FDG PET imaging in the localization of ictal epileptic foci METHODS 152 patients with epilepsy were examined ictally and interictally RESULTS During ictal studies, all patients showed increased regional cerebral glucose metabolism compared with that in interictal phase 65(42 8%) patients showed significant hypermetabolic foci, and 87(57 2%) patients showed relative hypermetabolism 80 patients had solitery focal hypermetabolic area Out of 72 patients with multi hypermetabolic foci, 49 were in adjacent areas CONCLUSIONS When both ictal and interictal scans were used together, the specificity of FDG PET imaging for the localization of epileptic foci could be elevated