放射性核素显像在骨缺损修复研究中的应用

Application of radionuclide SPECT imaging in assessment of bony defect repair

用ＳＰＥＣＴ检查骨缺损修复效果。４０只新西兰白兔均于两侧桡骨干造成１５ｃｍ缺损后分成４组，Ａ组植入２５ｍｇ骨形态发生蛋白（ＢＭＰ）与纤维蛋白的复合物；Ｂ组植入２５ｍｇＢＭＰ；Ｃ组单纯植入纤维蛋白；Ｄ组不植入任何材料。术后不同时间进行骨骼显像，同时进行放射学和组织学检查。结果术后１周发现再生性骨盐沉积活动，以Ａ组最为活跃，Ｂ组其次，所揭示规律与组织学和放射学检查结果吻合。因此，ＳＰＥＣＴ和常规检查方法联合应用，可以更早、更全面地评价骨缺损修复的效果。

PURPOSE To assess bony defect repair with SPECT imaging METHODS 40 New Zealand rabbits with 1 5cm bony defect on bilateral radius were divided into 4 groups with different implantation: A, composites of bone morphogenetic protein (BMP) and fibrin, B, BMP, C, fibrin, D, no implantation as control The defects were examined by multiphase imaging in different weeks after operation RESULTS The regenerative bone salt deposition was found one week after operation, the highest level of deposition was in group A, and the second in group B The bone regeneration revealed by SPECT imaging was in concordance with the results of histological and radiological examination CONCLUSIONS The combination use of SPECT and routine examination can assess bony defect repair more accurately and earlier