艾迪注射液治疗晚期恶性胸腔积液的临床观察

Clinical study of Aidi injection in the treatment of advanced malignant pleural effusion

目的：探讨艾迪注射液在恶性胸腔积液中的治疗效果。方法：对38例恶性肿瘤晚期合并恶性胸腔积液的病例采用胸腔灌注艾迪注射液（治疗组）100mL＋生理盐水60mL注入胸腔，每周一次，连用2～4周，并与36例胸腔灌注顺铂（对照组）60mg＋生理盐水60mL注入胸腔，每周一次，连用2～4周者进行疗效对比分析。结果：恶性胸腔积液治疗有效率治疗组为76．3％，对照组为81．6％，差异无显著性（P〉0．05）；治疗组与对照组KPS评分显效率、有效率分别为23．7％和42．1％，8．33％和19．4％，治疗组明显高于对照组，差异有显著性。治疗组的不良反应发生率明显低于对照组。结论：胸腔灌注艾迪注射液治疗恶性胸腔积液有一定的临床使用价值。

OBJECTIVE To investigate the significance of Aidi injection in malignant pleural effusion. METHODS Randomly dividing the cases with advanced malignant tumor with malignant pleural effusion into control group of Cisplatin ＋ NS 60 mL （38 cases） and treatment group of Aidi injection ＋ NS 60 mL （36 cases）. The control group and the treatment group were trea- ted respectively once a week for 2 - 4 weeks. Comparison of therapeutic effects was corducted. RESULTS Efficiency（CR ＋ PR） of pleural effusion treatment was 76. 3 % for treatment group, and 81.6%for control group with no significant difference between them （P〈0. 05）. Efficency KPS Evaluation in treatment group and control group were respectively 23.7% and 42.1%, 8.33% and 19. 4%. Wil：h significant difference （P〈0. 05）. The toxicity reaction of the treatment group was significantly lower than that of the control group. CONCLUSION Pleural perfusion with Aidi injection has some clinical significance in the treatment of malignant pleural effusion.