Br2-MnO2法合成12-溴脱氢松香酸及其甲酯

Synthesis of 12-Bromo-dehydroabietic Acid and 12-Bromo-methyl Dehydroabietate with Br_2-MnO_2

分别以Br2-冰醋酸、溴代丁二酰亚胺（NBS）和Br2-MnO2三种方法合成12-溴脱氢松香酸和12-溴脱氢松香酸甲酯，并对反应的动力学和不同体系的反应用时、产率、选择性以及合成成本等进行探究。研究表明：Br2-MnO2新方法反应条件温和，操作简单，反应用时短（2h），成本低，选择性好，产率较高（49％～66．7％），合成效率高，适合进一步工业化。

12-Bromo-dehydroabietic acid and 12-bromo-methyl dehydroabietate were synthesized with three bromide-system methods ,the Br2-acetic acid,NBS and Br2-MnO2 system,respectively. The reaction time,selectivity,yields and synthetic cost were studied in detail within these systems. The study demonstrate that,in comparison with the other two systems,the reaction time of the Br2-MnO2-system was shorter,and its synthetic cost was cheaper,but with higher selectivity and higher yields. Moreover the reaction completes in mild conditions and its operation is simple.