神经精神性狼疮43例分析

Clinical study of 43 cases with neuropsychiatric lupus erythematosus

目的 研究神经精神性狼疮(NPLE)的临床物点。方法 从330例住院的系统性红斑狼疮(SLE)患者中发现43例NPLE,并对其进行临床分析。结果 NPLE发生率占SLE的13％,且81.3％在起病后3年内发病,主要表现为抑郁、兴奋、癫痫、偏瘫等,影像学检查常见脑渗出性病变、小梗塞和钙化等,脑脊液检查:可有压力增高,蛋白和细胞增高。结论 早期作出诊断及积极治疗,多数预后良好。

Objective To study the clinical characteristics of 43 patients with neuropsychiatric lupus erythematosus (NPLE). Methods Analyzed the clinical characteristics of 43 patients with NPLE who were found from 330 patients with SLE in our hospital. Results It was found that the patients with NPLE were 13% (43/330) in the group of SLE. Most of the NPLE were ocurred in 3 years after SLE onset, and the main clinical manifestations were depression, psychosis, seizure and hemifestations. Cerebral CT scan and MRI scan showed cerebral atrophy, small infarct and calcification. Both proteins and cells in CSF were increased. Red blood cells could be found in CSF of few NPLE patients. Conclusions Most of the patients recovered well if proper treatment was carried out and early diagnose was made.