乳腺浸润性导管癌患者中Fhit基因的表达及其与雌、孕激素受体表达的相关性

Correlation and clinical significance of Fhit protein,estrogen and progesterone expression in breast cancer

目的:探讨乳腺浸润性导管癌组织中Fhit基因表达及其与雌激素受体(ER)、孕激素受体(PR)的关系。方法:采用免疫组化SP法检测128例乳腺浸润性导管癌及50例良性增生病变标本中Fhit基因及128例乳腺浸润性导管癌ER、PR的表达情况。结果:Fhit基因在乳腺浸润性导管癌病例中阳性表达率为27.34%(35/128),明显低于其在乳腺腺病中的阳性表达率70.00%(35/50)。差异有统计学意义(P<0.05)。在乳腺癌组织中,Fhit蛋白表达与组织学分级、腋窝淋巴结的转移的差异有统计学意义(P<0.05),与绝经情况、肿瘤长径、TNM分期差异无统计学意义(P>0.05)。通过相关性分析得出Fhit蛋白表达与ER及PR表达相关(P<0.05)。结论:联合检测乳腺癌组织ER、PR和Fhit蛋白的表达对于乳腺癌诊断、肿瘤恶性程度判定及预后有意义。

Objective： To analyze the Fhit gene expression in invasive ductal breast carcinoma and it＇s relationship between the estrogen receptor （ER） and progesterone receptor （PR）. Methods： Taking immunohistochemiatry streptavidin peroxidase （SP） method to detect the Fhit gene expression in 128 cases of invasire ductal breast cancer and 50 cases with benign lesions, and detecting the ER and PR expression in 128 cases ofinvasive ductal breast cancer. Results： The positive rate of Fhit protein in breast cancer tissues was lower than that in benign breast tumor, the difference was statistically significant （P〈0.05）. The expression of Fhit protein in breast cacinoma was correlated with the histological grade, lymph node metastasis, the difference was statistically significant （P〈0.05） and independence with tumor size, menopause, TNM stage （P 〉0.05）. The rank correlation drawn Fhit protein expression with ER and PR expression associated with statistical significance （P 〈0.05）. Conclusion： Fhit protein, ER and PR combined detection may help diagnosis and evaluate the malignant condition, prognosis of breast cacinoma.