摘要
作者应用免疫组化方法检测29例胃癌患者原发灶及其淋巴结转移灶等不同组织的α4和β1亚单位整合素在这情况，发现原发灶和淋巴结转移灶中α4、β1亚单位的染色特征发生明显改变。原发灶组和减淋巴结组的表达程度明显强于邻近非肿瘤胃粘膜组；在原发灶组中，α4、β1的表达强度与胃癌生长方式、分化程度、浸润深度、淋巴道和肝脏转移状况、Borrmann分型或TNM分期等临床病理因素密切相关。
Using immunohistochemical staining technic,expression of α4 and β1, subunits of integrins were investigated in different tissues from 29 specimens of gastric cancer (GC) including the primary tumor,regional lymph nodes and gastric mucosa nearby the tumor. It was found that the two subunits of integrins not only distributed disorderly in GC and metastatic foci but also overwhelmingly more intense than in the adjacent gastric mucosa. In the primary cancer the expression of α4,β1 was closely related with the growth pattern,cellular differentiation, depth of invasion and lymphatic or liver metastases. The bverexpression of α4,β1 might be predictors indicating the aggressive potential of gastric cancer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1997年第8期572-576,共5页
Chinese Journal of Clinical Oncology
基金
国家自然科学基金
关键词
胃肿瘤
肿瘤转移
细胞粘附分子
免疫组织化学
Cell adhesion molecules
Integrin
Immunohistochemistry
Stomach cancer
