养寿丹改善学习记忆功能的实验研究

Studies on Improving the Ability of Learning and Memories of Yangshoudan

目的：观察养寿丹对实验动物学习记忆功能的影响。方法：采用避暗法、跳台法和水迷路法研究养寿丹对正常幼龄小鼠及正常幼龄大鼠被动反应、樟柳碱所致小鼠记忆获得障碍，氢溴酸东莨菪碱所致小鼠记忆获得障碍、戊巴比妥钠所致小鼠方向辨别障碍及对老龄小鼠被动回避反应障碍的影响。结果：养寿丹能减少正常幼龄小鼠、正常幼龄大鼠５ｍｉｎ内学习试验及记忆测验的错误次数（Ｐ＜０．０５，Ｐ＜０．０１），可提高戊巴比妥钠造成的方向辨别障碍模型小鼠的正确反应平均数和正确反应百分率；并可缩短樟柳碱氢溴酸东莨菪碱所致记忆获得障碍模型小鼠或学习记忆障碍小鼠的记忆潜伏期，降低５ｍｉｎ内错误次数（Ｐ＜０．０５，Ｐ＜０．０１）。结论：养寿丹能增强正常动物的记忆功能，对药物所致记忆障碍动物及记忆障碍的老龄小鼠均有改善作用，初步显示养寿丹有改善学习记忆功能及抗痴呆的药理作用。

To observe the effects of Yangshoudan(YSD)on the ability of learning and memories in experimental animals. Methods: The tests of darkness-avoidance response in normal young mice and rats, aged mice, as well asin model mice with dysmnesia induced by anisodine, model rats with dysmnesia induced by scopolamine hydrobromide and with orientation disturbance induced by pentobarbital sodium. Results: In normal young mice and rats, theerror times in five minutes in learning and memories tests was reduced(P<0.01-0.05) by YSD, while in dysmnesia groups the error times in five minutes also reduced(P<0.01-0.05) and the incubation period of memoriescould be shortened by YSD. In orientation disturbance mice, the averages and percentages of correct response timesincreased by YSD. Conclusions: YSD could improve the memory ability both in normal and dysmnesia which eitherinduced by drugs or due to age. This indicates primarily that YSD has the effects of improving the ability of learningand memories and of antidementia.