凋亡抑制因子Livin在喉鳞状细胞癌组织中的表达及与碱性成纤维细胞生长因子的关系

Expression of Livin in laryngeal squamous cell carcinoma and relationship with bFGF

目的:观察喉鳞状细胞癌组织中凋亡抑制因子Livin的表达及与碱性成纤维细胞生长因子(bFGF)的关系,探讨Livin在喉鳞状细胞癌发病中的作用机制。方法:收集喉鳞状细胞癌标本41例(其中有淋巴结转移者11例)和正常软腭黏膜组织20例,用免疫组织化学染色法检测Livin和bFGF的表达情况。结果:喉鳞状细胞癌中Livin表达阳性率为70.73%(29/41),显著高于正常软腭黏膜组织(呈阴性表达);Livin在喉鳞状细胞癌中阳性率与淋巴结转移有关(P<0.05),未见与组织分化、临床分期和年龄相关(均P>0.05);Livin和bFGF在喉癌中的表达呈显著正相关。结论:Livin在喉鳞状细胞癌组织中的高度表达在喉鳞状细胞癌的发展中可能起重要作用,并可能和bFGF有协同作用。

Objective：To detect the roles of Livin and its relationship with bFGF in laryngeal squamous cell carcinoma（LSCC） through observing the expression of Livin and bFGF in laryngeal squamous cell carcinoma.Method：Expression of Livin and bFGF in 41 cases of LSCC（11 cases with lymph node metastasis） and 20 cases of normal soft palate mucosa were detected by immunohistochemistry.Result：Livin were positively detected in 29（70.73%） cases of LSCC and negatively detected in all normal soft palate tissue.The positive rate of Livin was higher in LSCC than that in normal soft palate tissue and the expressions were significantly associated with lymph node metastasis status（P〈0.05） but not with histological grade,clinical stage and age（P〉0.05）.The expression of Livin was positively correlated with the expression of bFGF.Conclusion：The elevated expression of Livin in LSCC might play an important role in the development of laryngeal squamous cell carcinoma and bFGF might be involved in the process.